Biomarkers Working Group
The Irish Longitudinal Study on Ageing (TILDA) is a population representative sample of 8,500 community-dwelling men and women aged ≥ 50 years. This study aims to monitor changes in health over time, and explore the complex interrelationships between bio-psycho-social factors and their impact on longevity and healthy ageing. At Wave 1 (2010) 6,000 participants also completed a comprehensive health assessment and 5,600 agreed to provide a blood sample. Plasma and buffy coats from non-fasting venous blood samples were collected and banked for future genetic and bio-marker studies.
Ethical approval for was obtained from the Trinity College Research Ethics committee and participants provided written informed consent prior to the collection of blood samples. We plan to collect additional samples in Waves 3 of the study (2014). Lipid profiles were obtained at Wave 1 and carotenoid analyses on banked plasma samples has been undertaken by the Vision group lead by Prof. Stephen Beatty and Dr. John Nolan at Waterford Institute of Technology (WIT). In Wave 3 (2014) we aim to expand on the types of samples that will be banked for future study.
We are beginning the process of identifying additional biomarkers and genetic markers of interest which may be assayed in relation to various physiological measures and outcomes. Expressions of interest in collaboration and utilisation of the TILDA Biobank resource are welcome.RESEARCH THEMES HOME